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Papers of the Week


Papers: 18 Jan 2025 - 24 Jan 2025


2025 Jan 17


J Neurosci Methods


39826699

A wireless optogenetic setup in freely moving mice for evaluation of cortical spreading depolarization in a chronic disease model.

Authors

Köhne A, Helgers SO, Kewitz B, Haupt RM, Oppermann V, Meinert F, Sánchez-Porras R, Said M, Woitzik J, Dömer P

Abstract

Spreading depolarization (SD) is an electrophysiological phenomenon of massive neuronal depolarization that occurs in a multitude of brain injuries. Clinical studies and experimental data have linked the occurrence of SDs with secondary brain damage. However, there is a translational gap because of methodological limitations between clinical and experimental approaches focusing on short-term effects. Moreover, usage of highly invasive SD triggers has put into question to what extent SDs themselves or the induction method had caused emergence of tissue damage.