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Papers of the Week
A triple cysteine motif as major determinant of the modulation of neuronal K7 channels by the paracetamol metabolite N-acetyl-p-benzo quinone imine.
Authors
Ray S, Stampf JL, Kudlacek O, Yang JW, Schicker KW, Graf Y, Losgott T, Boehm S, Salzer IAbstract
The analgesic action of paracetamol involves K7 channels, and its metabolite N-acetyl-p-benzo quinone imine (NAPQI), a cysteine modifying reagent, was shown to increase currents through such channels in nociceptors. Modification of cysteine residues by N-ethylmaleimide, HO, or nitric oxide has been found to modulate currents through K7 channels. The study aims to identify whether, and if so which, cysteine residues in neuronal K7 channels might be responsible for the effects of NAPQI.