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A review of the patent literature surrounding TRPV1 modulators.
Authors
Devesa I, Fernández-Ballester G, Fernandez-Carvajal A, Ferrer-Montiel AAbstract
TRPV1, a pivotal therapeutic target for chronic pain and pruritus, has been validated in the pathogenesis of several pathologies from diabetes to cancer. Despite the constellation of chemical structures and strategies, none of these molecules has been yet clinically developed as a new drug application due to safety concerns, particularly on thermoregulation. Thus, clinical development of TRPV1 modulators remains a challenge.