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Papers of the Week


Papers: 16 Sep 2023 - 22 Sep 2023

RESEARCH TYPE:
Basic Science, Psychology


Human Studies, Neurobiology, Neuroimaging

PAIN TYPE:
Inflammation/Inflammatory, Musculoskeletal Pain, Psychological/Comorbidities


2023 Sep 20


Arthritis Rheumatol


37727908

A Randomized, Controlled Neuroimaging Trial of Cognitive-Behavioral Therapy for Fibromyalgia Pain.

Authors

Lee J, Lazaridou A, Paschali M, Loggia ML, Berry MP, Ellingsen DM, Isenburg K, Anzolin A, Grahl A, Wasan AD, Napadow V, Edwards RR

Abstract

Fibromyalgia (FM) is characterized by pervasive pain-related symptomatology and high levels of negative affect. Mind-body treatments such as cognitive-behavioral therapy (CBT) appear to foster improvement in FM via reductions in pain-related catastrophizing, a set of negative, pain-amplifying cognitive and emotional processes. However, the neural underpinnings of CBT’s catastrophizing-reducing effects remain uncertain. This randomized, controlled, mechanistic trial was designed to assess CBT’s effects on pain catastrophizing and its underlying brain circuitry.