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Papers of the Week

Papers: 16 Sep 2023 - 22 Sep 2023

Basic Science, Psychology

Human Studies, Neurobiology, Neuroimaging

Inflammation/Inflammatory, Musculoskeletal Pain, Psychological/Comorbidities

2023 Sep 20

Arthritis Rheumatol


A Randomized, Controlled Neuroimaging Trial of Cognitive-Behavioral Therapy for Fibromyalgia Pain.


Lee J, Lazaridou A, Paschali M, Loggia ML, Berry MP, Ellingsen DM, Isenburg K, Anzolin A, Grahl A, Wasan AD, Napadow V, Edwards RR


Fibromyalgia (FM) is characterized by pervasive pain-related symptomatology and high levels of negative affect. Mind-body treatments such as cognitive-behavioral therapy (CBT) appear to foster improvement in FM via reductions in pain-related catastrophizing, a set of negative, pain-amplifying cognitive and emotional processes. However, the neural underpinnings of CBT’s catastrophizing-reducing effects remain uncertain. This randomized, controlled, mechanistic trial was designed to assess CBT’s effects on pain catastrophizing and its underlying brain circuitry.