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Papers of the Week

Papers: 18 May 2024 - 24 May 2024

2024 May 17

Trends Neurosci


A novel suppressor of Piezo2 in rodent nociceptors.


West AK, Schneider ER


Members of both the Piezo and transmembrane channel-like (TMC) families are bona fide mammalian mechanotransducers. In a recent study, Zhang, Shao et al. discovered that TMC7, a non-mechanosensitive TMC, inhibits Piezo2-dependent mechanosensation, with implications for the importance of cellular context for Piezo2 channels in normal and pathological responses to mechanical pain.