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Papers of the Week

Papers: 16 Dec 2023 - 22 Dec 2023

2023 Dec 19

Br J Pharmacol


A novel role of microtubule affinity-regulating kinases in neuropathic pain.


Shi YQ, Sun ZH, Wang ZZ, Su CY, Zhang W, Yu LY, Xu Y, Gao YL, Wang HB, Tian JW, Li CM


Neuropathic pain affects millions of patients but there are currently few viable therapeutic options available. Microtubule affinity-regulating kinases (MARKs) regulate the dynamics of microtubules and participate in synaptic remodeling. It is unclear whether these changes are involved in the central sensitization of neuropathic pain. This study examined the role of MARK1 or MARK2 in regulating neurosynaptic plasticity induced by neuropathic pain.