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Papers of the Week
A genome-wide association study of European advanced cancer patients treated with opioids identifies regulatory variants on chromosome 20 associated with pain intensity.
Authors
Minnai F, Shkodra M, Noci S, Esposito M, Brunelli C, Pigni A, Zecca E, Skorpen F, Klepstad P, Kaasa S, Corli O, Pallotti MC, Maltoni MC, Caraceni AT, Colombo FAbstract
Opioids in step III of the WHO analgesic ladder are the standard of care for treating cancer pain. However, a significant minority of patients do not benefit from therapy. Genetics might play a role in predisposing patients to a good or poor response to opioids. Here, we investigated this issue by conducting a genome-wide association study (GWAS).