I am a
Home I AM A Search Login

Papers of the Week

Papers: 30 Sep 2023 - 6 Oct 2023

2023 Sep 30

Clin Epigenetics




A DNA methylation signature in the stress driver gene Fkbp5 indicates a neuropathic component in chronic pain.


Maiarù M, Acton RJ, Woźniak EL, Mein CA, Bell CG, Géranton SM


Epigenetic changes can bring insight into gene regulatory mechanisms associated with disease pathogenicity, including chronicity and increased vulnerability. To date, we are yet to identify genes sensitive to epigenetic regulation that contribute to the maintenance of chronic pain and with an epigenetic landscape indicative of the susceptibility to persistent pain. Such genes would provide a novel opportunity for better pain management, as their epigenetic profile could be targeted for the treatment of chronic pain or used as an indication of vulnerability for prevention strategies. Here, we investigated the epigenetic profile of the gene Fkbp5 for this potential, using targeted bisulphite sequencing in rodent pre-clinical models of chronic and latent hypersensitive states.