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Papers of the Week

Papers: 29 Jul 2023 - 4 Aug 2023

2023 Aug 02

Curr Pain Headache Rep


A Brief Review of Gepants.


Li D, Abreu J, Tepper SJ


Gepants are small molecules that antagonize calcitonin gene-related peptide (CGRP) receptors. Due to their favorable side effect profile and versatility in treating headaches acutely and preventively, gepants are preferred over triptans. We will cover the indications for the four FDA-approved gepants in adults: rimegepant, atogepant, ubrogepant, and zavegepant. This review will illustrate how gepants will continue to revolutionize the acute and preventive treatment of headaches.