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Papers of the Week

2023 Feb 03

J Med Case Rep



Mifepristone induced liver injury in a patient with Cushing syndrome: a case report and review of the literature.


Ault TA, Braxton DR, Watson RA, Marcus AO, Fong T-L
J Med Case Rep. 2023 Feb 03; 17(1):33.
PMID: 36732814.


Mifepristone, also known as RU-486, is an anti-progestational steroid with similar chemical structure to anabolic steroids. Given as a single dose in conjunction with misoprostol, mifepristone is used to induce medical abortion. Mifepristone administered chronically at a higher dose is also approved for the management of hypercortisolism. There have been only 2 reported cases of mifepristone associated liver injury, in both cases, in the setting of Cushing syndrome. We report a third patient with Cushing syndrome with mifepristone induced liver injury with unique histological findings that provide insight to the pathophysiology of liver injury in mifepristone and anabolic steroids.