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Papers of the Week

Papers: 21 Jan 2023 - 3 Feb 2023

2023 Jan 09

Front Biosci (Landmark Ed)



Mast Cell-Associated Serotonin in Acupoint Contributes to Acupuncture Analgesia in Arthritis Rats by Mediating ATP Release.


Li B-R, Li Y-J, Xu J-W, Huang M, Wang L-N, Zhang D, Shen X-Y, Ding G-H
Front Biosci (Landmark Ed). 2023 Jan 09; 28(1):1.
PMID: 36722266.


The activation of subcutaneous mast cells (MCs) helps to trigger the analgesic effect induced by acupuncture (AP), a traditional oriental therapy, that has been gradually accepted worldwide. This work aimed to reveal whether the serotonin (5-hydroxytryptamine, 5-HT) released from MCs plays an important role in this process, which has a controversial effect in the mechanism of pain.