I am a
Home I AM A Search Login

Papers of the Week

Papers: 21 Jan 2023 - 3 Feb 2023

2023 Jan 31

Pain Manag

Epidural dexamethasone for acute postoperative pain management: a systematic review with meta-analysis.


Abdildin YG, Tapinova K, Nabidollayeva F, Viderman D
Pain Manag. 2023 Jan 31.
PMID: 36718798.


To study the effect of epidural dexamethasone in postoperative pain management. Random-effects meta-analysis was conducted in RevMan 5.4. We included nine randomized-controlled trials (RCT) with 657 patients. Dexamethasone demonstrated longer analgesia duration (mean difference 266.18 minutes, 95% CI [3.21,529.14]; p 0.05), lower incidence of nausea and vomiting during the first postoperative day (risk ratio 0.36, 95% CI [0.18,0.71]; p 0.004), and lower antiemetic requirements (risk ratio 0.33, 95% CI [0.14,0.79]; p 0.01). No difference in pain reduction and the length of hospital stay was observed between the groups. Dexamethasone was associated with a longer analgesic effect, a lower number of patients requiring antiemetics, and lower incidences of nausea and vomiting.