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Papers of the Week

2023 Jan 31

Curr Med Res Opin

Matching adjusted indirect comparison of acupuncture versus fremanezumab in the preventive treatment of episodic migraine.


Zheng H, Fan S-Q, Shi Y-Z, Liang J-T, Xiao X-Y
Curr Med Res Opin. 2023 Jan 31:1-26.
PMID: 36719716.


We acquired participant-level data from an acupuncture trial recruiting 302 participants and summary-level data from a fremanezumab trial recruiting 875 participants (290 participants received monthly fremanezumab [MF] and 291 received single-dose fremanezumab [SF]). The primary outcome was the mean reduction in monthly headache days. The secondary outcomes were the mean reduction in monthly moderate-to-severe headache days, days with acute medication, and the adverse events rate.