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Papers of the Week

Papers: 21 Jan 2023 - 3 Feb 2023


PLoS One



Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems.


Barry F, Chai F, Chijcheapaza-Flores H, Garcia-Fernandez M J, Blanchemain N, Nicot R
PLoS One. 2023; 18(1):e0281135.
PMID: 36719872.


To compare two agents that can induce a rat model of temporomandibular joint osteoarthritis (TMJOA) by chemical induction: monosodium iodoacetate (MIA) and collagenase type 2 (Col-2). We wished to ascertain the best agent for assessing drug-delivery systems (DDSs).