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Papers of the Week

2023 Jan 25

J Ethnopharmacol

Long-term oral administration of Asarum heterotropoides f. mandshuricum (Maxim.) Kitag. decoction and its aristolochic acid analogs do not cause renal toxicity in mice.


Liu M, Wang L, Qin S, Zhao Y, Liu S, Yi Y, Li C, Tian J, Liu C, Meng J, Wang Y, Zhang Y S, Wang F, Pan C, Han J, Tang X, Wang L, Liang A
J Ethnopharmacol. 2023 Jan 25:116202.
PMID: 36708883.


Asarum heterotropoides f. mandshuricum (Maxim.) Kitag. (AH) is widely used to treat influenza, COVID-19, allergic rhinitis, headache, toothache, rheumatoid arthritis, and peptic ulcer. However, its clinical use is controversial due to the concern of aristolochic acid nephropathy (AAN) caused by its component aristolochic acid analogs (AAs).