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Papers of the Week

Papers: 21 Jan 2023 - 3 Feb 2023


Front Pain Res (Lausanne)


Stress-induced changes in nociceptive responding post-surgery in preclinical rodent models.


Bella A, Diego AM, Finn DP, Roche M
Front Pain Res (Lausanne). 2022; 3:1106143.
PMID: 36703943.


Chronic post-surgical pain affects up to 85% of individuals depending on the type of surgery, the extent of inflammation, tissue and/or nerve damage. Pre-surgical stress is associated with greater pain intensity, prolonged recovery and is one of the main risk factors for the development of chronic post-surgical pain. Clinically valid animal models provide an important means of examining the mechanisms underlying the effects of stress on post-surgical pain and identifying potential novel therapeutic targets. This review discusses the current data from preclinical animal studies examining the effect of stress on post-surgical pain, the potential underlying mechanisms and gaps in the knowledge that require further investigation.