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Papers of the Week

2023 Jan 24

Ann Clin Transl Neurol

No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury.


Sachdeva R, Hosseinzadeh A, Rizzardo A, Maharaj A, Berger M, Krassioukov A
Ann Clin Transl Neurol. 2023 Jan 24.
PMID: 36692221.


Opioids effectively reduce chronic pain, but present significant side effects including opioid-induced constipation. Oxycodone/naloxone decreases pain and constipation in cancer patients, however its effect on spinal cord injury population remains understudied.