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Papers of the Week

Papers: 21 Jan 2023 - 3 Feb 2023

2023 Jan 21

Osteoarthritis Cartilage

IL-37 alleviates intervertebral disc degeneration via the IL-1R8/NF-κB pathway.


Li S, Pan X, Wu Y, Tu Y, Hong W, Ren J, Miao J, Wang T, Xia W, Lu J, Chen J, Hu X, Lin Y, Zhang X, Wang X
Osteoarthritis Cartilage. 2023 Jan 21.
PMID: 36693558.


Intervertebral disc degeneration (IDD) has been reported to be a major cause of low back pain. Interleukin (IL)-37 is an anti-inflammatory cytokine of the interleukin-1 family, which exerts salutary physiological effects. In this study, we assessed the protective effect of IL-37 on IDD progression and its underlying mechanisms.