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Papers of the Week

Papers: 21 Jan 2023 - 3 Feb 2023


Front Pain Res (Lausanne)


Analysis of , thermal and pressure pain thresholds, and stress in sickle cell disease.


Powell-Roach KL, Yao Y, Cao X, Chamala S, Wallace MR, Cruz-Almeida Y, Molokie RE, Wang Z J, Wilkie DJ
Front Pain Res (Lausanne). 2022; 3:1060245.
PMID: 36688082.


In patients with sickle cell disease (SCD), negative physical and emotional experiences result from intense chronic and acute pain episodes, but factors underlying these, and their interactions, are not well understood. The arginine vasopressin receptor 1a gene () single nucleotide polymorphism rs10877969 has been previously associated with aspects of acute pain and stress related pain. In this study, we tested for associations between this SNP, thermal and pressure pain thresholds, clinical pain, and stress in people with SCD.