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Papers of the Week

2023 Jan 19

J Urol

Detection of Bacteria in Bladder Mucosa of Adult Females.


Wolfe AJ, Rademacher DJ, Mores CR, Evans RJ, Overholt T, Halverson T, Limeira R, Matthews C, Badlani G, Brubaker L, Walker SJ
J Urol. 2023 Jan 19:101097JU0000000000003189.
PMID: 36657058.


Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic urological condition diagnosed in nearly 8 million females in the United States. Whether urinary microbiota play an etiologic role remains controversial. Most studies assessed the microbiota of IC/BPS patients with voided or catheterized urine as a proxy for bladder urothelium; however, urine may not be a true reflection of the bladder microbiota. Bladder biopsy tissue may provide a more accurate, and thus more clinically relevant, picture of bladder microbiota.