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Papers of the Week

Papers: 21 Jan 2023 - 3 Feb 2023


PLoS One



A meta-epidemiological study on the reported treatment effect of pregabalin in neuropathic pain trials over time.


Cheng ETL, Cheik-Hussein M, Lin N, Lewin AM, McAuley JH, Harris IA
PLoS One. 2023; 18(1):e0280593.
PMID: 36662848.


Pregabalin is a drug used to treat neuropathic pain, and its use has increased substantially since 2007. Early trials found a strong treatment effect on pain for post-herpetic neuralgia and diabetic neuropathy. However more recent studies have failed to replicate these results.