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Papers of the Week

Papers: 14 Jan 2023 - 20 Jan 2023

Pharmacology/Drug Development

2023 Jan 17

Br J Pharmacol

Differential regulation of Cav3.2 and Cav2.2 calcium channels by CB1 receptors and cannabidiol.


Harding EK, Souza IA, Gandini MA, Gadotti VM, Ali M Y, Huang S, Antunes FTT, Trang T, Zamponi GW
Br J Pharmacol. 2023 Jan 17.
PMID: 36647671.


Cannabinoids represent a promising therapeutic avenue for chronic pain, however clinical trials often fail to report analgesic efficacy of cannabinoids. Inhibition of voltage-gated calcium channels is one mechanism through which cannabinoids may produce analgesia. We hypothesized that cannabinoids and cannabinoid receptor agonists target different types of voltage gated calcium channels through distinct mechanisms.