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Papers: 14 Jan 2023 - 20 Jan 2023

2023 Jan 17

Psychopharmacology (Berl)

Unravelling the dorsal periaqueductal grey matter NMDA receptors relevance in the nitric oxide-mediated panic‑like behaviour and defensive antinociception organised by the anterior hypothalamus of male mice.


Falconi-Sobrinho L L, Dos Anjos-Garcia T, Hernandes P M, de Rodrigues B M P, Almada R C, Coimbra N C
Psychopharmacology (Berl). 2023 Jan 17.
PMID: 36648509.


Previous studies suggested that the dorsal column of the periaqueductal grey matter (dPAG) can be a target of neural pathways from hypothalamic nuclei involved in triggering fear-related defensive responses. In turn, evidence is provided suggesting that microinjection of the nitric oxide (NO) donor SIN-1 into the anterior hypothalamus (AH) of mice evokes panic-like behaviours and fear-induced antinociception. However, it is unknown whether the dPAG of mice mediates these latter defensive responses organised by AH neurons.