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Papers of the Week

Papers: 14 Jan 2023 - 20 Jan 2023


2023 Jan 17

JAMA Neurol

Management of Trigeminal Autonomic Cephalalgias Including Chronic Cluster: A Review.


Diener H C, Tassorelli C, Dodick DW
JAMA Neurol. 2023 Jan 17.
PMID: 36648786.


Trigeminal autonomic cephalalgias (TACs) comprise a unique collection of primary headache disorders characterized by moderate or severe unilateral pain, localized in in the area of distribution of the first branch of the trigeminal nerve, accompanied by cranial autonomic symptoms and signs. Most TACs are rare diseases, which hampers the possibility of performing randomized clinical trials and large studies. Therefore, knowledge of treatment efficacy must be based only on observational studies, rare disease registries, and case reports, where real-world data and evidence play an important role in health care decisions.