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Papers of the Week

2023 Jan 13

Ann Pharmacother

Comparison of Sedation and Analgesia Requirements in Patients With SARS-CoV-2 Versus Non-SARS-CoV-2 Acute Respiratory Distress Syndrome on Veno-Venous ECMO.


Sigala MI, Dreucean D, Harris JE, Donahue KR, Bostan F, Voore P, Cuevas J, Morton C
Ann Pharmacother. 2023 Jan 13:10600280221147695.
PMID: 36639872.


Increased analgosedation requirements have been described in patients with acute respiratory distress syndrome (ARDS) on extracorporeal membrane oxygenation (ECMO) support due to unique pharmacokinetic challenges. There is a paucity of data comparing sedation requirements in patients on ECMO for ARDS secondary to SARS-CoV-2 versus other etiologies of respiratory failure.