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Papers of the Week

2023 Jan 12

Eur J Anaesthesiol

Additive or synergistic analgesic effect of metamizole on standard pain treatment at home after arthroscopic shoulder surgery: A randomised controlled superiority trial.


Stessel B, Lambrechts M, Evers S, Vanderstappen C, Callebaut I, Ory J-P, Herbots J, Dreesen I, Vaninbroukx M, Van de Velde M
Eur J Anaesthesiol. 2023 Jan 12.
PMID: 36632758.


There is growing evidence that the analgesic effect of metamizole is mediated at least partly by central mechanisms, including the endocannabinoid/endovanilloid system. Consequently, metamizole may have additive or even synergistic analgesic effects with paracetamol and nonsteroidal anti-inflammatory drugs (NSAID).