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Papers of the Week

Papers: 7 Jan 2023 - 13 Jan 2023

Human Studies


2023 Jan 11


A Cross-Trait, Mendelian Randomization Study to Investigate Whether Migraine Is a Risk Factor for Multiple Sclerosis.


Horton MK, Robinson SC, Shao X, Quach H, Quach D, Choudhary V, Bellesis KH, Dorin P, Mei J, Chinn T, Meyers TJ, Bakshi N, Marcus JF, Waubant E, Schaefer CA, Barcellos LF
Neurology. 2023 Jan 11.
PMID: 36631270.


Migraine is common among people with multiple sclerosis (MS), but the reasons for this are unknown. We tested three hypothesized mechanisms for this observed comorbidity, including migraine is a risk factor for MS, genetic variants are shared between the conditions, and migraine is a result of MS.