I am a
Home I AM A Search Login

Papers of the Week

Papers: 7 Jan 2023 - 13 Jan 2023

2023 Jan 06


Editor's Pick

Catechol-O-Methyltransferase Loss Drives Cell-Specific Nociceptive Signaling via the Enteric COMT/miR-155/TNF-α Axis.


Zhou Q, Yang L, Verne ML, Zhang BB, Fields J, Verne G N
Gastroenterology. 2023 Jan 06.
PMID: 36623778.


The etiology of abdominal pain in post-infectious, diarrhea-predominant IBS (PI-IBS-D) is unknown and few treatment options exist. Catechol-O-methyltransferase (COMT), an enzyme that inactivates and degrades biologically active catecholamines, plays an important role in numerous physiologic processes, including modulation of pain perception. Our objective was to determine the mechanism(s) of how decreased colonic COMT in PI-IBS-D patients contributes to the chronic abdominal pain phenotype following enteric infections.