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Papers of the Week

2022 Dec 21




Beneficial Effects of in the DCA Experimental Model of Irritable Bowel Syndrome in Rats.


Rodríguez-Sojo M J, Garcia-Garcia J, Ruiz-Malagón A J, Diez-Echave P, Hidalgo-García L, Molina-Tijeras J A, González-Lozano E, López-Escanez L, Rodríguez-Cabezas M E, Rodríguez-Sánchez M J, Rodríguez-Nogales A, Mediavilla C, Galvez J
Nutrients. 2022 Dec 21; 15(1).
PMID: 36615683.


, a probiotic strain isolated from human milk, has reported beneficial effects on different gastrointestinal disorders. Moreover, it has shown its ability to restore altered immune responses, in association with microbiome modulation in different pathological conditions. Therefore, our aim was to assess the effects of a in a rat experimental model of irritable bowel syndrome (IBS) that resembles human IBS. The experimental IBS was induced by deoxycholic acid (DCA) in rats and then, (10 CFU/day/rat) was administered. Behavioral studies, hyperalgesia and intestinal hypersensitivity determinations were performed and the impact of the probiotic on the inflammatory and intestinal barrier integrity was evaluated. Additionally, the gut microbiota composition was analyzed. attenuated the anxiety-like behavior as well as the visceral hypersensitivity and referred pain. Moreover, this probiotic ameliorated the gut inflammatory status, re-establishing the altered intestinal permeability, reducing the mast cell degranulation and re-establishing the gut dysbiosis in experimental IBS. Therefore, our results suggest a potential use of in clinical practice for the management of IBS patients.