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Front Neurol


Different effects of air microembolism through patent foramen ovale in patients with migraine: A quantitative electroencephalogram case series.


Ornello R, Spezialetti M, Caponnetto V, Frattale I, Grappasonni M, Pistoia F, Placidi G, Sacco S
Front Neurol. 2022; 13:1034714.
PMID: 36601292.


Literature suggests an association between patent foramen ovale (PFO) and migraine, mostly migraine with aura (MA). Previous data suggest that air microembolism through PFO can lead to bioelectrical abnormalities detectable at electroencephalogram (EEG) in patients with MA, thus suggesting a pathophysiological mechanism for the MA-PFO association. However, those data lack replication.