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Papers of the Week

2023 Jan 03


Reactogenicity and safety of second trimester maternal tetanus, diphtheria and acellular pertussis vaccination in the Netherlands.


Immink MM, Kemmeren JM, Broeders L, Bekker MN, de Melker HE, Sanders EAM, van der Maas NAT
Vaccine. 2023 Jan 03.
PMID: 36604217.


Maternal tetanus-diphtheria-and-acellular-pertussis (Tdap) vaccination is offered to all pregnant women during their second trimester in the Netherlands since December 2019. We assessed second trimester Tdap vaccination reactogenicity and compared with third trimester data from a similar study. For safety assessment, adverse pregnancy outcomes were compared with national data from 2018, before Tdap vaccine-introduction.