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Papers of the Week

2023 Jan 05

Int J Low Extrem Wounds

Effects of Citric Acid on the Healing Process of Chronic Wound due to Leprosy.


Passos J R D, Sangaleti C T, Trincaus M R, Prezotto K H, de Araújo L O, Techy B, Baratieri T, Lentsck M H, Taques G R, Moreira R C, da Silva D C
Int J Low Extrem Wounds. 2023 Jan 05:15347346221147398.
PMID: 36604854.


The aim was to describe the effects of the use of citric acid in the healing process of chronic leprosy wounds. This is a case series, carried out with 5 people with chronic leprosy wounds, under continuous care in an outpatient center wound care in the center-south region of Brazil. The intervention protocol consisted of topical application of 3% citric acid (ointment), on the wound bed, in a thin layer of approximately 2 mm, on alternate days, and followed up for a total period of 8 weeks and secondary coverage rayon and gauze. The cases were analyzed regarding wound dimensions, histology and clinical observation. It was observed in all cases better aspect of the wound bed, presence of granulation tissue and decrease of the inflammatory process with predominance of lymphocytes, reduction of bacterial colonies, increase and verticalization of type I collagen fibers, reduction of type III collagen and increased areas of epithelialization. There was also a reduction in the level of pain and exudation after the treatment protocol. Therefore, the use of citric acid in leprosy neuropathic wounds is promising and may be a treatment option, considering its cost, clinical management and possible effect on the chronic inflammatory process.