I am a
Home I AM A Search Login

Papers of the Week


Front Med (Lausanne)


Case report: Eosinophilic fasciitis induced by pembrolizumab with high FDG uptake on F-FDG-PET/CT.


Amrane K, Le Meur C, Thuillier P, Alemany P, Niel C, Renault D, Abgral R
Front Med (Lausanne). 2022; 9:1078560.
PMID: 36606046.


Eosinophilic fasciitis (EF) is a rare connective tissue disorder causing inflammation and fibrosing of fascia. In this study, we present a very rare case of an immune checkpoint inhibitor (ICI)-induced EF revealed by F-fluorodesoxyglucose positron emission tomography (FDG-PET/CT) 20 months after the initiation of Pembrolizumab treatment of a relapsed non-small cell lung cancer (NSCLC). This study presents a 52-year-old Caucasian woman clinically presenting asthenia, inflammatory muscle, and joint pain associated with subcutaneous nodules and symmetrical edema of the lower limbs. Iterative FDG-PET/CT scans allow us to guide the therapeutic strategy due to this atypical ICI adverse event.