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Papers of the Week

2023 Jan 06

Medicine (Baltimore)



Idiopathic intracranial hypertension in patients with cerebral small vessel disease: A case report.


Liu W, Jia L, Xu L, Yang F, Cheng H, Li H, Hou J, Zhang D, Liu Y
Medicine (Baltimore). 2023 Jan 06; 102(1):e32639.
PMID: 36607854.


Idiopathic intracranial hypertension (IIH) is a clinical syndrome characterized by increased intracranial pressure (ICP) without any identifiable cause. However, restrictions of cerebrospinal fluid absorption from the cerebral venous system, the glymphatic system overflow, and the cerebrospinal fluid's lymphatic pathways may be involved in the pathophysiology of IIH. Furthermore, an impaired glymphatic system is also implicated in the initiation and progression of cerebral small vessel disease (CSVD). Here, we reported a case of CSVD with concomitant IIH, possibly associated with the brain's glymphatic and lymphatic system dysfunction.