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Front Immunol


Dupilumab improves clinical symptoms in children with Netherton syndrome by suppressing Th2-mediated inflammation.


Yan S, Wu X, Jiang J, Yu S, Fang X, Yang H, Bai X, Wang H, Luo X
Front Immunol. 2022; 13:1054422.
PMID: 36569942.


Netherton syndrome is a rare, life-threatening autosomal recessive genetic disorder with no effective treatment yet. Skin barrier dysfunction caused by gene mutations is a hallmark of the disease. Antigen penetration through the defective skin and nonspecific inflammation provide a pro-T helper 2 (Th2) immune microenvironment in the disease. Therefore, Th2 cytokines are considered to be candidate therapeutic targets.