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Papers of the Week

Papers: 24 Dec 2022 - 30 Dec 2022

2022 Dec 16




A Fenchone Derivative Effectively Abrogates Joint Damage Following Post-Traumatic Osteoarthritis in Lewis Rats.


Carmon I, Smoum R, Farhat E, Reich E, Kandel L, Yekhtin Z, Gallily R, Mechoulam R, Dvir-Ginzberg M
Cells. 2022 Dec 16; 11(24).
PMID: 36552848.


In a previous report, we have identified the cannabinoid receptor 2 (CB2) agonist HU308 to possess a beneficial effect in preventing age and trauma-induced osteoarthritis (OA) in mice. The effects of HU308 were largely related to the capacity of this compound to induce cartilage anabolism which was dependent on the CREB/SOX9 axis, and exhibited pro-survival and pro-proliferative hallmarks of articular cartilage following treatment. Here, we utilized the novel cannabinoid-fenchone CB2 agonists (1B, 1D), which were previously reported to render anti-inflammatory effects in a zymosan model.