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Papers of the Week

2022 Dec 23

Arthritis Res Ther



Neuronal CRMP2 phosphorylation inhibition by the flavonoid, naringenin, contributes to the reversal of spinal sensitization and arthritic pain improvement.


Jiang Y-P, Wang S, Lai W-D, Wu X-Q, Jin Y, Xu Z-H, Moutal A, Khanna R, Park K D, Shan Z-M, Wen C-P, Yu J
Arthritis Res Ther. 2022 Dec 23; 24(1):277.
PMID: 36564853.


Rheumatoid arthritis patients usually suffer from arthritic chronic pain. However, due to an incomplete understanding of the mechanisms underlying autoimmune disorders, the management of arthritic pain is unsatisfactory. Here, we investigated the analgesic effect and underlying mechanism of the natural flavonoid naringenin (NAR) in collagen-induced arthritis (CIA) pain.