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Toxicol Rep


Topiramate intoxications & hemodialysis – Literature review and the first case report of a massive suicidal intoxication treated with hemodialysis.


Schutte T, van Tellingen A, van den Broek J, Ten Brink M, van Agtmael-Boerrigter MG
Toxicol Rep. 2022; 9:1639-1646.
PMID: 36561947.


Topiramate is an anticonvulsant from sulfamate-substituted monosaccharides that is increasingly used to treat migraines. Serious topiramate intoxications have been described. Unfortunately, indications for and the effect of interventions, including hemodialysis, in severe intoxications seem expert-based and lack empirical evidence. We aim to review the literature on topiramate intoxication cases and to describe the first topiramate intoxication with toxicokinetic data following treatment with hemodialysis.