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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / TRPV1 and TRPM8 antagonists reduce cystitis-induced bladder hypersensitivity via inhibition of different sensitised classes of bladder afferents in guinea pigs.

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Papers: 17 Dec 2022 - 23 Dec 2022


2022 Dec 22


Br J Pharmacol


http://www.ncbi.nlm.nih.gov/pubmed/36549668?dopt=Abstract

TRPV1 and TRPM8 antagonists reduce cystitis-induced bladder hypersensitivity via inhibition of different sensitised classes of bladder afferents in guinea pigs.

Authors

TRPV1 and TRPM8 antagonists reduce cystitis-induced bladder hypersensitivity via inhibition of different sensitised classes of bladder afferents in guinea pigs.
Ramsay S, Keightley L, Brookes S, Zagorodnyuk V
Br J Pharmacol. 2022 Dec 22.
PMID: 36549668.

Abstract

Interstitial cystitis (=painful bladder syndrome) is a chronic bladder syndrome characterised by pelvic and bladder pain, urinary frequency and urgency, and nocturia. Transient receptor potential (TRP) channels are an attractive target in reducing the pain associated with interstitial cystitis. The current study aims to determine the efficacy of combination of TRP vanilloid 1 (TRPV1) and TRP melastatin 8 (TRPM8) channel inhibition in reducing the pain associated with experimental cystitis in guinea pigs.
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