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Papers of the Week

Papers: 17 Dec 2022 - 23 Dec 2022

2022 Dec 22

Mol Pain

Folic acid attenuates chronic visceral pain by reducing Clostridiales abundance and hydrogen sulfide production.


Weng R-X, Wei Y-X, Li Y-C, Xu X, Zhuang J-B, Xu G-Y, Li R
Mol Pain. 2022 Dec 22:17448069221149834.
PMID: 36550612.


Irritable bowel syndrome (IBS) related chronic visceral pain affects 20% of people worldwide. The treatment options are very limited. Although the scholarly reviews have appraised the potential effects of the intestinal microbiota on intestinal motility and sensation, the exact mechanism of intestinal microbiota in IBS-like chronic visceral pain remains largely unclear. The purpose of this study is to investigate whether Folic Acid (FA) attenuated visceral pain and its possible mechanisms.