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gy2022-1-3
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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / IκB kinase ε contributes to the pathogenesis of osteoarthritis by promoting cartilage degradation.

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Papers: 17 Dec 2022 - 23 Dec 2022


2022 Dec 18


Arthritis Rheumatol


http://www.ncbi.nlm.nih.gov/pubmed/36530063?dopt=Abstract

IκB kinase ε contributes to the pathogenesis of osteoarthritis by promoting cartilage degradation.

Authors

IκB kinase ε contributes to the pathogenesis of osteoarthritis by promoting cartilage degradation.
Uchida T, Akasaki Y, Sueishi T, Kurakazu I, Toya M, Kuwahara M, Hirose R, Hyodo Y, Tsushima H, Lotz MK, Nakashima Y
Arthritis Rheumatol. 2022 Dec 18.
PMID: 36530063.

Abstract

Nuclear factor kappa B (NF-κB) signaling is an important modulator in osteoarthritis (OA), and IκB kinase ε (IKKε) regulates the NF-κB pathway. This study was undertaken to identify the functional involvement of IKKε and the effectiveness of IKKε inhibition in OA pathogenesis.
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