I am a
Home I AM A Search Login

Papers of the Week

Papers: 17 Dec 2022 - 23 Dec 2022

2022 Dec 18

Arthritis Rheumatol

IκB kinase ε contributes to the pathogenesis of osteoarthritis by promoting cartilage degradation.


Uchida T, Akasaki Y, Sueishi T, Kurakazu I, Toya M, Kuwahara M, Hirose R, Hyodo Y, Tsushima H, Lotz MK, Nakashima Y
Arthritis Rheumatol. 2022 Dec 18.
PMID: 36530063.


Nuclear factor kappa B (NF-κB) signaling is an important modulator in osteoarthritis (OA), and IκB kinase ε (IKKε) regulates the NF-κB pathway. This study was undertaken to identify the functional involvement of IKKε and the effectiveness of IKKε inhibition in OA pathogenesis.