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Papers of the Week

2023 Jan 01

Anesth Analg



Postcesarean Analgesia With Epidural Morphine After Epidural 2-Chloroprocaine: A Randomized Noninferiority Trial.


Lee LO, Ramirez-Chapman A L, White DL, Zhang X, Lu M, Suresh MS
Anesth Analg. 2023 Jan 01; 136(1):86-93.
PMID: 36534717.


Previous studies have suggested that administration of epidural 3% 2-chloroprocaine (CP) before epidural morphine results in decreased analgesic efficacy of epidural morphine. We sought to determine whether these observations were a result of antagonism or a window period between the conclusion of surgical anesthesia for cesarean delivery and the peak onset time of epidural morphine, and whether a method to preserve the analgesic efficacy of epidural morphine exists.