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Papers of the Week

Papers: 17 Dec 2022 - 23 Dec 2022

2022 Dec 14

J Orthop Sci

Central sensitization adversely affects quality of recovery following lumbar decompression surgery.


Mui T, Iwata E, Nakajima H, Sada T, Tanaka M, Okuda A, Kawasaki S, Shigematsu H, Tanaka Y
J Orthop Sci. 2022 Dec 14.
PMID: 36526518.


Central sensitization (CS) is defined as increased responsiveness of nociceptive neurons in the central nervous system to normal or subthreshold afferent input. The CS phenomenon is caused by continuous, intense nociceptor inputs triggering a prolonged but reversible increase in the excitability and synaptic efficacy of neurons in the central nociceptive pathway. Most patients undergoing surgery for lumbar spinal stenosis (LSS) experience symptoms for more than three months; therefore, it is possible that CS is associated with postoperative symptoms of LSS. The aim of this study was to clarify the influence of CS in patients who underwent surgery for LSS.