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Papers of the Week

Papers: 10 Dec 2022 - 16 Dec 2022

Human Studies, Pharmacology/Drug Development

2022 Dec 14

BMJ Support Palliat Care

Naldemedine versus placebo in opioid-induced constipation: a meta-analysis.


Wobbe B, Gerner M, Köhne C-H
BMJ Support Palliat Care. 2022 Dec 14.
PMID: 36517204.


Opioid-induced constipation (OIC) is a frequent adverse event among patients receiving chronic pain therapy that is requiring opioids. Naldemedine was approved by the Food and Drug Administration to treat OIC and appears to be more efficient than any other peripherally acting µ-opioid receptor antagonist. This meta-analysis aimed at assessing the available data on naldemedine in terms of efficacy.