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Papers of the Week

Papers: 10 Dec 2022 - 16 Dec 2022

Animal Studies

2022 Dec 12

Br J Pharmacol

Soluble epoxide hydrolase inhibition enhances Specialized Pro-resolving Lipid Mediator production and promotes macrophage plasticity.


Abdalla HB, Alvarez C, Wu Y-C, Rojas P, Hammock BD, Maddipati KR, Trindade-da-Silva C A, Soares MQS, Clemente-Napimoga JT, Kantarci A, Napimoga MH, Van Dyke TE
Br J Pharmacol. 2022 Dec 12.
PMID: 36508312.


Epoxyeicosatrienoic acids (EETs) and other epoxy fatty acids (EpFA) are lipid mediators that are rapidly inactivated by soluble epoxide hydrolase. Uncontrolled and chronic inflammatory disorders fail to sufficiently activate endogenous regulatory pathways, including the production of specialized pro-resolving mediators (SPMs). Here, we addressed the relationship between SPMs and the EET/sEH axis and explored the impact of sEH inhibition on resolving macrophage phenotype.