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Papers of the Week

Papers: 10 Dec 2022 - 16 Dec 2022

Animal Studies

2022 Dec 10

J Nanobiotechnology



Extracellular vesicles from IFN-γ-primed mesenchymal stem cells repress atopic dermatitis in mice.


Kim J M, Lee S K, Jung M, Jeong S-Y, You H, Won J-Y, Han S-D, Cho H J, Park S, Park J, Kim T, Kim S
J Nanobiotechnology. 2022 Dec 10; 20(1):526.
PMID: 36496385.


Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by immune dysregulation, pruritus, and abnormal epidermal barrier function. Compared with conventional mesenchymal stem cell (MSC), induced pluripotent stem cell (iPSC)-derived mesenchymal stem cell (iMSC) is recognized as a unique source for producing extracellular vesicles (EVs) because it can be obtained in a scalable manner with an enhanced homogeneity. Stimulation of iMSCs with inflammatory cytokines can improve the immune-regulatory, anti-inflammatory, and tissue-repairing potential of iMSC-derived EVs.