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Papers of the Week

2022 Nov 30

J Clin Med



Hypercoagulability and Inflammatory Markers in a Case of Congenital Thrombotic Thrombocytopenic Purpura Complicated by Fetal Demise.


Skeith L, Hurd K, Chaturvedi S, Chow L, Nicholas J, Lee A, Young D, Goodyear D, Soucie J, Girard L, Dufour A, Agbani EO
J Clin Med. 2022 Nov 30; 11(23).
PMID: 36498688.


Congenital thrombotic thrombocytopenic purpura (cTTP) is a rare disorder caused by an inherited genetic deficiency of ADAMTS13 and affects less than one per million individuals. Patients who are diagnosed with TTP during pregnancy are at increased risk of maternal and fetal complications including fetal demise. We present a case of a 32-year-old G3P0 (gravida 3, para 0) who presented at 20 weeks gestation with a new diagnosis of congenital TTP (cTTP) and fetal demise.