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Papers of the Week

2022 Nov 30

Nanomaterials (Basel)



Evaluation of Biocompatibility, Anti-Inflammatory, and Antinociceptive Activities of Pequi Oil-Based Nanoemulsions in In Vitro and In Vivo Models.


Pinheiro AC, Ombredane AS, Pinheiro WO, Andrade LR, Silva VRP, Felice GJ, Alves DS, Albernaz AF, Silveira AP, Lima MCF, Veiga-Junior VF, Gomes TFS, Damasceno EAM, Veiga-Souza FH, Souza PEN, Báo SN, Duarte ECB, Carneiro MLB, Azevedo RB, Funez MI, et al.
Nanomaterials (Basel). 2022 Nov 30; 12(23).
PMID: 36500883.


Pequi oil () contains bioactive compounds capable of modulating the inflammatory process; however, its hydrophobic characteristic limits its therapeutic use. The encapsulation of pequi oil in nanoemulsions can improve its biodistribution and promote its immunomodulatory effects. Thus, the objective of the present study was to formulate pequi oil-based nanoemulsions (PeNE) to evaluate their biocompatibility, anti-inflammatory, and antinociceptive effects in in vitro (macrophages-J774.16) and in vivo () models. PeNE were biocompatible, showed no cytotoxic and genotoxic effects and no changes in body weight, biochemistry, or histology of treated animals at all concentrations tested (90-360 µg/mL for 24 h, in vitro; 100-400 mg/kg p.o. 15 days, in vivo). It was possible to observe antinociceptive effects in a dose-dependent manner in the animals treated with PeNE, with a reduction of 27 and 40% in the doses of 100 and 400 mg/kg of PeNE, respectively ( < 0.05); however, the treatment with PeNE did not induce edema reduction in animals with carrageenan-induced edema. Thus, the promising results of this study point to the use of free and nanostructured pequi oil as a possible future approach to a preventive/therapeutic complementary treatment alongside existing conventional therapies for analgesia.