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Papers of the Week


2022 Dec 06


J Ethnopharmacol

Influence of pyrrolizidine alkaloids depletion upon the biological activity of Symphytum officinale L. extracts.

Authors

Trifan A, Czerwińska ME, Zengin G, Esslinger N, Grubelnik A, Wolfram E, Skalicka-Woźniak K, Luca S V
J Ethnopharmacol. 2022 Dec 06:116010.
PMID: 36493995.

Abstract

Comfrey (Symphytum officinale L., Boraginaceae) root preparations are used as both traditional remedies and therapeutic agents in treating pain and inflammation associated with joint, bone, and muscle ailments. Even though numerous phytochemicals contribute to the beneficial effects of comfrey, the presence of toxic pyrrolizidine alkaloids (PAs) overshadows its uses.