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Papers of the Week

2022 Dec 09

BMC Neurol



Prolonged neurologic deficits with brain MRI changes following ECT in an adolescent with a CACNA1a-related disorder; a case report.


Vithayathil J, Freeman C, Jacobwitz M, Schwartz E S, Agarwal S
BMC Neurol. 2022 Dec 09; 22(1):466.
PMID: 36494636.


Electroconvulsive therapy is used to treat depression and schizophrenia with infrequent use in pediatric patients. We report a case of an adolescent with autism spectrum disorder and acute catatonia that presented with status epilepticus (SE) and prolonged neurologic deficits with unilateral left cerebral edema on imaging following unilateral electroconvulsive therapy (ECT) on the right side, subsequently found to have a CACNA1a pathogenic variant. This case highlights a potential adverse effect of ECT in patients with CACNA1a related disorders.